Lipopolysaccharide Regulation of Toll-Like Receptor-4 and Matrix Metalloprotease-9 in Human Primary Corneal Fibroblast Cells.

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Lipopolysaccharide Regulation of Toll-Like Receptor-4 and Matrix Metalloprotease-9 in Human Primary Corneal Fibroblast Cells.

Wong, Y., Sethu, C., Louafi, F., Hossain, P.

Journal		Invest Ophthalmol Vis Sci.
Species
Analytes Measured		GM-CSF , IL-10 , IL-12 p70 , IL-2 , IL-6 , IL-8
Matrix Tested		Tissue culture supernatants

Year		2011
Volume		52
Page Numbers		2796-2803
Application		Cytokines and Chemokines

Abstract

PURPOSE: Toll-like receptor 4 (TLR4) is a key component of the innate immune response related to microbial keratitis (MK). Pathways and downstream effectors relating to TLR signaling remain unknown in human bacterial MK. To this effect, by activating the TLR4 signaling cascade with lipopolysaccharide (LPS), the authors investigated whether TLR4, matrix metalloproteases (MMP)-2, MMP-9, and cytokine expression in diseased human primary corneal fibroblasts (CFs) were altered.

METHODS: Human primary CFs from patients with severe corneal ulceration were cultured in conjunction with healthy control CFs and treated with LPS derived from Pseudomonas aeruginosa.

RESULTS: TLR4, MMP-2, and MMP-9 were constitutively expressed in both ulcerated and control CFs. Diseased CFs showed greater responsiveness to LPS stimulation. TLR4 and MMP-9 expression was dose-dependently increased by LPS. MMP-2 expression was not affected by LPS. Analysis on cytokine expression revealed that IL-2, IL-8, IL-10, IL-12p70, GM-CSF, IFNγ, and TNFα expression increased after LPS treatment but only in diseased cells.

CONCLUSIONS: TLR4 activation with LPS increases TLR4, MMP-9, and cytokine expression in CFs cultured from patients with microbial keratitis. Overexpression of these products may provide a local mechanism to eradicate bacterial infection but may also aid corneal ulceration and perforation.

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V-PLEX Custom Human Biomarkers 1 C-Peptide, CRP, Eotaxin, Eotaxin-3, FGF (basic), GIP (active), GLP-1 (active), Glucagon, GM-CSF, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-1RA, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17A/F, IL-17B, IL-17C, IL-17D, Insulin, IP-10, Leptin, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, PP, SAA, TARC, Tie-2, TNF-α, TNF-β, TSLP, VCAM-1, VEGF-A, VEGF-C, VEGF-D, VEGFR-1/Flt-1 \| Human Multiplex
V-PLEX Custom Mouse Biomarkers IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-17A/F, IL-27p28/IL-30, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, TNF-α \| Mouse Multiplex
V-PLEX Custom NHP Biomarkers 1 C-Peptide, Eotaxin, Eotaxin-3, GIP (active), GLP-1 (active), Glucagon, GM-CSF, IFN-γ, IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, Insulin, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PP, TARC, TNF-β, VEGF-A \| Non-human primate Multiplex
V-PLEX Human IL-12p70 Kit IL-12p70 \| Human Singleplex
V-PLEX Human IL-8 Kit IL-8 \| Human Singleplex
V-PLEX NHP IL-8 Kit IL-8 \| Non-human primate Singleplex
V-PLEX Plus Human IL-12p70 Kit IL-12p70 \| Human Singleplex
V-PLEX Plus Human IL-8 Kit IL-8 \| Human Singleplex
V-PLEX Plus NHP IL-8 Kit IL-8 \| Non-human primate Singleplex
V-PLEX Plus Human IL-10 Kit IL-10 \| Human Singleplex
V-PLEX NHP IL-10 Kit IL-10 \| Non-human primate Singleplex
V-PLEX Human IL-10 Kit IL-10 \| Human Singleplex
V-PLEX Plus NHP IL-10 Kit IL-10 \| Non-human primate Singleplex
V-PLEX Plus NHP IL-2 Kit IL-2 \| Non-human primate Singleplex
V-PLEX Plus Human IL-2 Kit IL-2 \| Human Singleplex
V-PLEX NHP IL-2 Kit IL-2 \| Non-human primate Singleplex
V-PLEX Human IL-2 Kit IL-2 \| Human Singleplex
V-PLEX Plus NHP GM-CSF Kit GM-CSF \| Non-human primate Singleplex
V-PLEX Plus Human GM-CSF Kit GM-CSF \| Human Singleplex
V-PLEX NHP GM-CSF Kit GM-CSF \| Non-human primate Singleplex
V-PLEX Human GM-CSF Kit GM-CSF \| Human Singleplex
V-PLEX Plus NHP IL-6 Kit IL-6 \| Non-human primate Singleplex
V-PLEX Plus Human IL-6 Kit IL-6 \| Human Singleplex
V-PLEX NHP IL-6 Kit IL-6 \| Non-human primate Singleplex
V-PLEX Human IL-6 Kit IL-6 \| Human Singleplex
V-PLEX Plus Cytokine Panel 1 NHP Kit GM-CSF, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A \| Non-human primate Multiplex
V-PLEX Plus Cytokine Panel 1 Human Kit GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A \| Human Multiplex
V-PLEX Cytokine Panel 1 NHP Kit GM-CSF, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A \| Non-human primate Multiplex
V-PLEX Cytokine Panel 1 Human Kit GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A \| Human Multiplex
V-PLEX Human Proinflammatory Panel I (4-Plex) IFN-γ, IL-1β, IL-6, TNF-α \| Human Multiplex
V-PLEX Viral Panel 2 NHP Kit IFN-γ, IL-1β, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Viral Panel 2 Human Kit IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α \| Human Multiplex
V-PLEX Viral Panel 1 NHP Kit IL-1β, IL-6, IL-8 \| Non-human primate Multiplex
V-PLEX Viral Panel 1 Human Kit IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Plus Viral Panel 2 NHP Kit IFN-γ, IL-1β, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Plus Viral Panel 2 Human Kit IFN-γ, IL-1β, IL-4, IL-6, IL-8, IL-10, TNF-α \| Human Multiplex
V-PLEX Plus Viral Panel 1 NHP Kit IL-1β, IL-6, IL-8 \| Non-human primate Multiplex
V-PLEX Plus Viral Panel 1 Human Kit IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Plus Proinflammatory Panel 1 NHP Kit IFN-γ, IL-1β, IL-2, IL-6, IL-8, IL-10 \| Non-human primate Multiplex
V-PLEX Plus Human Proinflam. Panel II (4-Plex) IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Plus Human Proinflam. Panel I (4-Plex) IFN-γ, IL-1β, IL-6, TNF-α \| Human Multiplex
V-PLEX Human Proinflammatory Panel II (4-Plex) IL-1β, IL-6, IL-8, TNF-α \| Human Multiplex
V-PLEX Proinflammatory Panel 1 Human Kit IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α \| Human Multiplex
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Lipopolysaccharide Regulation of Toll-Like Receptor-4 and Matrix Metalloprotease-9 in Human Primary Corneal Fibroblast Cells.

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